Lewandowski heaped massive praise on Ronaldo and said Poland must stand up together to stop Portugal, who have several individual talents in their side.
Fernandes was shown a second booking in the 81st minute for a high boot that caught defender Nehuen Perez as he tried to connect with a cross into the box.
A third defeat in United's first six league games of the new campaign leaves the Red Devils down in 11th and time surely running out for their beleaguered boss.
Sam Lammers capitalised on a mistake by Christian Eriksen in the second half at Old Trafford and raced away to fire an equalizer for the Dutch underdog.